Congratulations Inga!

New paper in Nature

The long-awaited structure of full-length, human NLRP3 is here! Inga and colleagues have done a great job determining the cryo-EM structure of this inflammasomal protein in the inactive state bound to the inhibitor CRID3. In solution, the protein forms a decamer composed as pentamer of dimers. We identify a binding site that ties together five subdomains to keep the protein locked in the inactive state. This structure opens a wide field for optimization and development of other inflammation-targeting inhibitors as new medicines. Read the full story here.