Institute of Structural Biology
University of Bonn
Welcome to our Institute! We are interested in the structure–function relationship of biological macromolecules. We use molecular biology techniques, biochemistry, biophysics, X-ray crystallography and cryo electron microscopy to investigate biological phenomena at atomic resolution.
New paper in JBC
Robert, Ines and Max just published a paper on the di-alcohol 1,6-hexanediol, showing that this organic chemical impairs the enzymatic activity of transcription kinases. This has a great impact on the interpretation of phosphorylation reactions in intrinsically disordered regions, as hexanediol is widely used to dissolve liquid-liquid phase separated condensates....
New paper in JMB
Martin, Niels, Janin and Gregor just published a paper about how the binding of substrates triggers the open-closed transition of the P-domain of the sialic acid TRAP transporter HiSiaQM. This was a collaboration with the laboratory of Thorben Cordes at the LMU and Gavin Thomas at the University of York....
New paper in FEBS Letters
Our paper "Crystal structure of the human NLRP9 pyrin domain suggests a distinct mode of inflammasome assembly" has just been published in FEBS Letters. We made the cover page and there is a Commentary Article by Eva de Alba....
