Institute of Structural Biology
University of Bonn

Welcome to our Institute!  We are interested in the structure–function relationship of biological macromolecules.  We use molecular biology techniques, biochemistry, biophysics, X-ray crystallography and cryo electron microscopy to investigate biological phenomena at atomic resolution.  

In a recent paper published in JACI, our Postdoc Jonas together with collaborators from Melbourne investigated a common variant of the inflammasome-forming NLRP1 protein, identifying functional consequences and links to asthma. Findings from this study may have implications for the treatment of asthmatic individuals carrying this variant of the NLRP1 sensor.The project was kicked off as a successful collaboration with the lab of Seth Masters during Jonas' PhD as part of the Bonn & Melbourne ...

Robert, Ines, Max and Matthias just published a paper on the di-alcohol 1,6-hexanediol, showing that this organic chemical impairs the enzymatic activity of transcription kinases. This has a great impact on the interpretation of phosphorylation reactions in intrinsically disordered regions, as hexanediol is widely used to dissolve liquid-liquid phase separated condensates....

Martin, Niels, Janin and Gregor just published a paper about how the binding of substrates triggers the open-closed transition of the P-domain of the sialic acid TRAP transporter HiSiaQM. This was a collaboration with the laboratory of Thorben Cordes at the LMU and Gavin Thomas at the University of York....
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