Institute of Structural Biology
University of Bonn

Welcome to our Institute!  We are interested in the structure–function relationship of biological macromolecules.  We use molecular biology techniques, biochemistry, biophysics, X-ray crystallography and cryo electron microscopy to investigate biological phenomena at atomic resolution.  

Robert, Ines, Max and Matthias just published a paper on the di-alcohol 1,6-hexanediol, showing that this organic chemical impairs the enzymatic activity of transcription kinases. This has a great impact on the interpretation of phosphorylation reactions in intrinsically disordered regions, as hexanediol is widely used to dissolve liquid-liquid phase separated condensates....

Martin, Niels, Janin and Gregor just published a paper about how the binding of substrates triggers the open-closed transition of the P-domain of the sialic acid TRAP transporter HiSiaQM. This was a collaboration with the laboratory of Thorben Cordes at the LMU and Gavin Thomas at the University of York....

Our paper "Crystal structure of the human NLRP9 pyrin domain suggests a distinct mode of inflammasome assembly" has just been published in FEBS Letters. We made the cover page and there is a Commentary Article by Eva de Alba....
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