Robert – who is now in the Fisher lab at MSSM, New York – published a great paper on Cdk10/Cyclin Q in Open Biology. Cyclin-dependent kinases (CDKs) perform multiple tasks in cells, e.g., coordination of cell division or gene regulation by phosphorylating proteins. Inhibition of these kinases shows promising effects in various cancers, raising hope for improved therapies. Robert generated highly purified preparations of Cdk10/CycQ, which allowed him to analyse its enzymatic activity and test preclinical inhibitors. A particular mutation helped us to specifically label and identify new protein substrates, which was performed in collaboration with the Urlaub lab from Göttingen. These data will help us understand how Cdk10 acts during development or in cancer.
