Inga and Matthias wrote a review article on the “Structural aspects of inflammasome-forming NOD-like receptors” for the book Fundamentals of Inflammasome Biology, edited by Pablo Pelegrín. In this review, they provide a state-of-the-art overview of the NLR family of proteins, from conserved sequence motifs to the quaternary assembly of the inflammasome; involving NLRP or NLRC sensory proteins, the adaptor ASC, and pro-caspases as downstream effectors. They discuss whether all NLRs function according to a similar mechanism and whether targeted inhibition appears feasible for the specific treatment of inflammatory diseases. Read this review here.
