A new way to inhibit pyroptosis! Anja characterized by biochemical means six nanobodies that were raised against human Gasdermin D. All of them bind to the N-terminal domain of this membrane rupturing protein, but three specifically block the assembly of the membrane pore. She succeeded in crystallizing full length Gasdermin D together with two nanobodies and determined the structure at 1.9 Å resolution, providing first structural insights into the mode of action of nanobody-based Gasdermin D inhibition. Read the full story here.
