Congratulations to Jan Gerhartz, Dominika Pieńkowska, Ina Dressel and Thomas Geiger on a paper in Cell Chemical Biology.
An engineered cereblon optimized for high throughput screening and molecular glue discovery - now in Cell Chemical Biology. Congratulations Jan Gerhartz, Dominika Pieńkowska, Ina Dressel and Thomas Geiger.
CRBN is one of the most popular E3 ligases in the Targeted Protein Degradation space, but it requires a complex with adapter protein DDB1 to express well. This new soluble CRBN construct enables, high yield expression, rapid screening for novel CRBN binders and can also be used for CRBN interactome assessment with molecular glues. A great collaboration with the Dikic Lab, Enamine Germany, Merck Group, the Langer Lab Max Planck Institute of Biophysics and iBET - Instituto de Biologia Experimental e Tecnológica.
You can read the full article here:
https://www.sciencedirect.com/science/article/pii/S2451945624004604
Animation by PROXIDRUGs team.